Protective Mechanisms Against DNA Replication Stress in the Nervous System.

ABSTRACT: The precise replication of DNA and the successful segregation of chromosomes are essential for the faithful transmission of genetic information during the cell cycle. Alterations in the dynamics of genome replication, also referred to as DNA replication stress, may lead to DNA damage and, consequently, mutations and chromosomal rearrangements. Extensive research has revealed that DNA replication stress drives genome instability during tumorigenesis. Over decades, genetic studies of inherited syndromes have established a connection between the mutations in genes required for proper DNA repair/DNA damage responses and neurological diseases. It is becoming clear that both the prevention and the responses to replication stress are particularly important for nervous system development and funct

SUBMITTER: Charlier CF 

PROVIDER: S-EPMC7397197 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature