Flavonoids as Potential Drugs for VPS13-Dependent Rare Neurodegenerative Diseases.

ABSTRACT: Several rare neurodegenerative diseases, including chorea acanthocytosis, are caused by mutations in the VPS13A-D genes. Only symptomatic treatments for these diseases are available. Saccharomyces cerevisiae contains a unique VPS13 gene and the yeast vps13Δ mutant has been proven as a suitable model for drug tests. A library of drugs and an in-house library of natural compounds and their derivatives were screened for molecules preventing the growth defect of vps13Δ cells on medium with sodium dodecyl sulfate (SDS). Seven polyphenols, including the iron-binding flavone luteolin, were identified. The structure-activity relationship and molecular mechanisms underlying the action of luteolin were characterized. The FET4 gene, which encodes an ir

SUBMITTER: Soczewka P 

PROVIDER: S-EPMC7397310 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature