CD4⁺ T-Cell Responses Mediate Progressive Neurodegeneration in Experimental Ischemic Retinopathy.

ABSTRACT: Retinal ischemic events, which result from occlusion of the ocular vasculature share similar causes as those for central nervous system stroke and are among the most common cause of acute and irreversible vision loss in elderly patients. Currently, there is no established treatment, and the condition often leaves patients with seriously impaired vision or blindness. The immune system, particularly T-cell-mediated responses, is thought to be intricately involved, but the exact roles remain elusive. We found that acute ischemia-reperfusion injury to the retina induced a prolonged phase of retinal ganglion cell loss that continued to progress during 8 weeks after the procedure. This phase was accompanied by microglial activation and CD4⁺ T-cell infiltration into the retina. Adoptiv

SUBMITTER: Khanh Vu TH 

PROVIDER: S-EPMC7397460 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature