Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC7397478 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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Imbalance in T follicular helper cells producing IL-17 promotes pro-inflammatory responses in MuSK antibody positive myasthenia gravis.
Li Yingkai Y Guptill Jeffrey T JT Russo Melissa A MA Howard James F JF Massey Janice M JM Juel Vern C VC Hobson-Webb Lisa D LD Emmett Doug D Chopra Manisha M Raja Shruti S Liu Weibin W Yi John S JS
Journal of neuroimmunology 20200527
A detailed understanding of the role of Tfh cells in MuSK-antibody positive myasthenia gravis (MuSK-MG) is lacking. We characterized phenotype and function of Tfh cells in MuSK-MG patients and controls. We found similar overall Tfh and follicular regulatory (Tfr) T cell frequencies in MuSK-MG and healthy controls, but MuSK-MG patients exhibited higher frequencies of Tfh17 cells and a higher ratio of Tfh:Tfr cells. These results suggest imbalanced Tfh cell regulation, further supported by increas ...[more]
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