Distinct modes of action of CD40L and adaptive cytokines IL-2, IL-4/13, IL-10 and IL-21 on rainbow trout IgM⁺ B cells.

ABSTRACT: In mammals, conventional B (B2) cells are activated within lymphoid follicles through a close relationship with T follicular helper (Tfh) cells. The interaction between CD40 expressed on B cells and its ligand (CD40L) expressed on Tfh cells is a key signal that regulates the formation of germinal centers (GCs), B cell survival, proliferation and differentiation to plasma cells (PCs) or memory cells. Additionally, certain soluble cytokines produced by T cells also strongly condition the outcome of this interaction. Despite the many differences found between fish B cells and mammalian B2 cells, and the lack of conventional GCs, rainbow trout IgM⁺ B cells have been shown to be stimulated by CD40L, however, whether cytokines commonly produced by T cells can further modulate this res

SUBMITTER: Abos B 

PROVIDER: S-EPMC7397517 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature