Mapping epigenetic modifications on chicken lampbrush chromosomes.

ABSTRACT:

Background

The epigenetic regulation of genome is crucial for implementation of the genetic program of ontogenesis through establishing and maintaining differential gene expression. Thus mapping of various epigenetic modifications to the genome is relevant for studying the regulation of gene expression. Giant transcriptionally active lampbrush chromosomes are an established tool for high resolution physical mapping of the genome and its epigenetic modifications. This study is aimed at characterizing the epigenetic status of compact chromatin domains (chromomeres) of chicken lampbrush macrochromosomes.

Results

Distribution of three epigenetic modifications - 5-methylcytosine, histone H3 trimethylated at lysine 9 and hyperacetylated histone H4 - along the axes of chicken lampb

SUBMITTER: Kulikova T 

PROVIDER: S-EPMC7397634 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature