Risk factors for cutaneous reactions to allopurinol in Kinh Vietnamese: results from a case-control study.

ABSTRACT:

Objective

The aim of this study was to investigate risk factors for cutaneous adverse reactions (CARs) in Kinh Vietnamese.

Methods

All patients were prospectively recruited in Ho Chi Minh City. Presence of the HLA-B*58:01 allele was determined by real-time PCR-sequence-specific amplification by using the PG5801 Detection Kit (Pharmigene, Taipei). Patients with severe (SCARs) and mild (MCARs) CARs and controls were compared for differences in features prospectively collected, and odds ratios (ORs) with 95% confidence intervals (CIs) were estimated.

Results

On comparing 32 patients with SCARs and 395 tolerant controls, we identified eight strong risk factors: increased age (OR 15.1 [95% CI 5.8-40.1], P < 0.0001), female sex (OR 333 [40-43,453], P < 0.0001), allopurinol

SUBMITTER: Do MD 

PROVIDER: S-EPMC7397637 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature