The frequency and inter-relationship of PD-L1 expression and tumour mutational burden across multiple types of advanced solid tumours in China.

ABSTRACT:

Background

PD-L1 expression and tumour mutational burden (TMB) are both associated with the responses of multiple tumours to immune checkpoint inhibitor (ICI) therapy. However, their prevalence and correlations may differ in different types of advanced solid tumours.

Methods

PD-L1 expression, TMB, and PD-1⁺ Tils (tumour-infiltrating lymphocytes) infiltration and their relationships were assessed in 6668 advanced solid tumour specimens across 25 tumour types. CD8⁺ T cell infiltration was analysed in 347 NSCLC samples. The associations of these biomarkers with the therapeutic effect of PD-1 inhibitor were analysed in a cohort of NSCLC samples.

Results

PD-L1 expression levels and TMB in different tumour types varied widely and their relationship was

SUBMITTER: Chen Y 

PROVIDER: S-EPMC7397649 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature