Furosemide and spironolactone doses and hyponatremia in patients with heart failure.

ABSTRACT:

Background

Hyponatremia, a marker of disease severity and prognosis, has been associated with various clinical factors and drug use, especially diuretics.

Methods

This observational prospective cohort study enrolled patients hospitalized at the University Hospital Center Split because of heart failure (HF). We investigated the association of clinical variables and cardiovascular drugs, including furosemide, hydrochlorothiazide, spironolactone, and their doses, with the presence of hyponatremia at admission.

Results

Of the 565 included patients, 32.4% were hyponatremic, 62.6% were males, and the mean age was 73.1 ± 10.6 years. In the univariate analysis, hyponatremic patients were more often current smokers (p = 0.01), alcohol consumers (p = 0.01), receiving spironolac

SUBMITTER: Velat I 

PROVIDER: S-EPMC7397681 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature