Increased prediction value of biomarker combinations for the conversion of mild cognitive impairment to Alzheimer's dementia.

ABSTRACT:

Background

Progression of mild cognitive impairment (MCI) to Alzheimer's disease (AD) dementia can be predicted by clinical features and a combination of biomarkers may increase the predictive power. In the present study, we investigated whether the combination of olfactory function and plasma neuronal-derived exosome (NDE) Aβ_1-42 can best predict progression to AD dementia.

Methods

87 MCI patients were enrolled and received the cognitive assessment at 2-year and 3-year follow-up to reevaluate cognition. In the meanwhile, 80 healthy controls and 88 AD dementia patients were enrolled at baseline as well to evaluate the diagnose value in cross-section. Olfactory function was evaluated with the sniffin sticks (SS-16) and Aβ_1-42 levels in NDEs were determin

SUBMITTER: Zhao A 

PROVIDER: S-EPMC7397685 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature