The protein kinase PknB negatively regulates biosynthesis and trafficking of mycolic acids in mycobacteria.

ABSTRACT: Mycobacterium tuberculosis is the causative agent of tuberculosis and remains one of the most widespread and deadliest bacterial pathogens in the world. A distinguishing feature of mycobacteria that sets them apart from other bacteria is the unique architecture of their cell wall, characterized by various species-specific lipids, most notably mycolic acids (MAs). Therefore, targeted inhibition of enzymes involved in MA biosynthesis, transport, and assembly has been extensively explored in drug discovery. Additionally, more recent evidence suggests that many enzymes in the MA biosynthesis pathway are regulated by kinase-mediated phosphorylation, thus opening additional drug-development opportunities. However, how phosphorylation regulates MA production remains unclear. Here, we used

SUBMITTER: Le NH 

PROVIDER: S-EPMC7397745 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature