Examining Cognitive Decline Across Black and White Participants in the Harvard Aging Brain Study.

ABSTRACT:

Background

Black Americans are approximately twice as likely to develop dementia as compared to White Americans and the magnitude of this disparity is often attributed to a variety of factors that include psychosocial and vascular risk factors. However, less is known about the potential contribution of Alzheimer's disease pathological differences.

Objective

To examine potential differences incross-sectional and longitudinal cognitive performance in black and white participants who were clinically normal at baseline.

Methods

296 participants (48 African-American/black participants) underwent MRI and amyloid PET at baseline. Linear mixed models were used to examine the main effects of race, years of education, reading ability, Framingham Heart Study cardiovascular risk

SUBMITTER: Amariglio RE 

PROVIDER: S-EPMC7397774 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature