Vitamin D Metabolism Is Dysregulated in Asthma and Chronic Obstructive Pulmonary Disease.

ABSTRACT: Rationale: Vitamin D deficiency is common in patients with asthma and chronic obstructive pulmonary disease (COPD). Low 25-hydroxyvitamin D (25[OH]D) levels may represent a cause or a consequence of these conditions.Objectives: To determine whether vitamin D metabolism is altered in asthma or COPD.Methods: We conducted a longitudinal study in 186 adults to determine whether the 25(OH)D response to six oral doses of 3 mg vitamin D₃, administered over 1 year, differed between those with asthma or COPD versus control subjects. Serum concentrations of vitamin D₃, 25(OH)D₃, and 1α,25-dihydroxyvitamin D₃ (1α,25[OH]₂D₃) were determined presupplementation and postsupplementation in 93 adults with asthma, COPD, o

SUBMITTER: Jolliffe DA 

PROVIDER: S-EPMC7397796 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature