The Role of Epstein-Barr Virus in Adults With Bronchiectasis: A Prospective Cohort Study.

ABSTRACT:

Background

Epstein-Barr virus (EBV) is implicated in the progression of chronic obstructive pulmonary disease. We aimed to determine whether EBV correlates with bronchiectasis severity, exacerbations, and progression.

Methods

We collected induced sputum in healthy controls and spontaneous sputum at 3-6-month intervals and onset of exacerbations in bronchiectasis patients between March 2017 and October 2018. EBV DNA was detected with quantitative polymerase chain reaction.

Results

We collected 442 sputum samples from 108 bronchiectasis patients and 50 induced sputum samples from 50 healthy controls. When stable, bronchiectasis patients yielded higher detection rates of EBV DNA (48.1% vs 20.0%; P = .001), but not viral loads (mean log₁₀ load, 4.45 vs 4

SUBMITTER: Chen CL 

PROVIDER: S-EPMC7397835 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature