Comparative transcriptomics of primary cells in vertebrates.

ABSTRACT: Gene expression profiles in homologous tissues have been observed to be different between species, which may be due to differences between species in the gene expression program in each cell type, but may also reflect differences in cell type composition of each tissue in different species. Here, we compare expression profiles in matching primary cells in human, mouse, rat, dog, and chicken using Cap Analysis Gene Expression (CAGE) and short RNA (sRNA) sequencing data from FANTOM5. While we find that expression profiles of orthologous genes in different species are highly correlated across cell types, in each cell type many genes were differentially expressed between species. Expression of genes with products involved in transcription, RNA processing, and transcriptional regulation was mor

SUBMITTER: Alam T 

PROVIDER: S-EPMC7397866 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature