Early Detection and Prevention of Alzheimer's Disease: Role of Oxidative Markers and Natural Antioxidants.

ABSTRACT: Oxidative stress (OS) contributes to Alzheimer's disease (AD) pathology. OS can be a result of increased reactive oxygen/nitrogen species, reduced antioxidants, oxidatively damaged molecules, and/or a combination of these factors. Scientific literature is scarce for the markers of OS-specific for detecting AD at an early stage. The first aim of the current review is to provide an overview of the potential OS markers in the brain, cerebrospinal fluid (CSF), blood and/or urine that can be used for early diagnosis of human AD. The reason for exploring OS markers is that the proposed antioxidant therapies against AD appear to start too late to be effective. The second aim is to evaluate the evidence for natural antioxidants currently proposed to prevent or treat AD symptoms. To address these t

SUBMITTER: Arslan J 

PROVIDER: S-EPMC7397955 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature