Application of antibody phage display to identify potential antigenic neural precursor cell proteins.

ABSTRACT:

Background

The discovery of neural precursor cells (NPCs) and the concomitant intensive research in the field offer regenerative medicine novel approaches, enabling it to tackle conditions, such as neurodegenerative diseases. Transplantation of NPCs is nowadays considered a cutting-edge treatment for these conditions and many related clinical trials have been already completed or are still ongoing. However, little is known about the antigenicity of NPCs, with most studies addressing the question whether their antigenicity could lead to rejection of the transplanted cells.

Results

In this study we investigated the antigenic potential of syngeneic NPCs emulsion, upon subcutaneous (s.c.) administration to wild type C57BL/6 mice, following a standard immunization protocol. The w

SUBMITTER: Paspaltsis I 

PROVIDER: S-EPMC7398072 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature