The SLC36 transporter Pathetic is required for neural stem cell proliferation and for brain growth under nutrition restriction.

ABSTRACT:

Background

Drosophila neuroblasts (NBs) are neural stem cells whose maintenance relies on Notch activity. NBs proliferate throughout larval stages to generate a large number of adult neurons. Their proliferation is protected under conditions of nutrition restriction but the mechanisms responsible are not fully understood. As amino acid transporters (Solute Carrier transporters, SLCs), such as SLC36, have important roles in coupling nutrition inputs to growth pathways, they may have a role in this process. For example, an SLC36 family transporter Pathetic (Path) that supports body size and neural dendrite growth in Drosophila, was identified as a putative Notch target in genome-wide studies. However, its role in sustaining stem cell proliferation and maintenance has not been investi

SUBMITTER: Feng S 

PROVIDER: S-EPMC7398078 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature