In silico molecular docking analysis for repurposing therapeutics against multiple proteins from SARS-CoV-2.

ABSTRACT: SARS-CoV-2 has devastated the world with its rapid spread and fatality. The researchers across the globe are struggling hard to search a drug to treat this infection. Understanding the time constraint, the best approach is to study clinically approved drugs for control of this deadly pandemic of COVID 19. The repurposing of such drugs can be supported with the study of molecular interactions to enhance the possibility of application. The present work is a molecular docking study of proteins responsible for viral propagation namely 3Clpro, Nsp10/16, Spike protein, SARS protein receptor binding domain, Nsp 9 viral single strand binding protein and viral helicase. The protein through virus enters the host cell-human angiotensin-converting enzyme 2 (ACE2) receptor, is also used as a target for

SUBMITTER: Deshpande RR 

PROVIDER: S-EPMC7398085 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature