Assessment of Hepatocellular Carcinoma Response to ⁹⁰Y Radioembolization Using Dynamic Contrast Material-enhanced MRI and Intravoxel Incoherent Motion Diffusion-weighted Imaging.

ABSTRACT:

Purpose

To quantify diffusion and perfusion changes in hepatocellular carcinoma (HCC) induced by yttrium 90 (⁹⁰Y) radioembolization and to assess the value of dynamic contrast material-enhanced (DCE) MRI and intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for predicting HCC response.

Materials and methods

Institutional review board approval was obtained for this prospective study (clinical trial registry NCT01871545). Twenty-four participants with HCC (mean age, 69 years ± 9 [standard deviation], 18 men) underwent multiparametric MRI, including IVIM DWI and gadoxetic acid DCE MRI before (n = 24) and 6 weeks (n = 21) after radioembolization. IVIM DWI and DCE MRI histogram parameters were quantified in HCCs and liver parenchyma. HC

SUBMITTER: Hectors SJ 

PROVIDER: S-EPMC7398117 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature