SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle.

ABSTRACT:

Background and purpose

In addition to the central nervous system-mediated action, leptin also directly induces fatty acid oxidation in skeletal muscle. Rapid induction of FAO by leptin is mediated by the AMP-activated protein kinase (AMPK) pathway, but the mechanism of prolonged FAO by leptin was previously unknown. In an earlier study, we showed that free fatty acids increase transcription of small ubiquitin-like modifier (SUMO) specific protease 2 (SENP2) in skeletal muscle, and that SENP2 stimulates expression of FAO-associated enzymes by deSUMOylating peroxisome proliferator-activated receptors, PPARδ and PPARγ. In this study, we examine whether SENP2 is involved in prolonged stimulation of FAO by leptin.

Methods

The Effect of leptin on expression of SENP2 and on SENP2-m

SUBMITTER: Koo YD 

PROVIDER: S-EPMC7398119 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature