IgE autoantibodies and autoreactive T cells and their role in children and adults with atopic dermatitis.

ABSTRACT: The pathophysiology of atopic dermatitis (AD) is highly complex and understanding of disease endotypes may improve disease management. Immunoglobulins E (IgE) against human skin epitopes (IgE autoantibodies) are thought to play a role in disease progression and prolongation. These antibodies have been described in patients with severe and chronic AD, suggesting a progression from allergic inflammation to severe autoimmune processes against the skin. This review provides a summary of the current knowledge and gaps on IgE autoreactivity and self-reactive T cells in children and adults with AD based on a systematic search. Currently, the clinical relevance and the pathomechanism of IgE autoantibodies in AD needs to be further investigated. Additionally, it is unknown whether the presence of I

SUBMITTER: Badloe FMS 

PROVIDER: S-EPMC7398196 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature