Efficacy of benralizumab for patients with severe eosinophilic asthma: a retrospective, real-life study.

ABSTRACT:

Background

Benralizumab, an anti-interleukin-5 (IL-5) receptor α monoclonal antibody, significantly reduces the number of annual exacerbations and oral corticosteroid (OCS) maintenance doses for patients with severe eosinophilic asthma (SEA). However, few studies on the efficacy of this biologic in real life are available. The aim was to elucidate the efficacy of benralizumab by evaluating changes in clinical parameters after benralizumab treatment in patients with SEA.

Methods

From July 2018 to December 2019, 24 Japanese patients with SEA received benralizumab at Jikei University Hospital. We retrospectively evaluated the patients' characteristics, parameters, numbers of exacerbations and maintenance OCS doses.

Results

Among the 24 patients, eleven patients had recei

SUBMITTER: Numata T 

PROVIDER: S-EPMC7398222 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature