Low-arginine and low-protein diets induce hepatic lipid accumulation through different mechanisms in growing rats.

ABSTRACT:

Background

Dietary protein deficiency and amino acid imbalance cause hepatic fat accumulation. We previously demonstrated that only arginine deficiency or total amino acid deficiency in a diet caused significant hepatic triglyceride (TG) accumulation in young Wistar rats. In this study, we explored the mechanisms of fatty liver formation in these models.

Methods

We fed 6-week-old male Wistar rats a control diet (containing an amino acid mixture equivalent to 15% protein), a low-total-amino acid diet (equivalent to 5% protein; 5PAA), and a low-arginine diet (only the arginine content is as low as that of the 5PAA diet) for 2 weeks.

Results

Much greater hepatic TG accumulation was observed in the low-arginine group than in the low-total-amino acid group. The lipid consu

SUBMITTER: Otani L 

PROVIDER: S-EPMC7398226 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature