Occupancy maps of 208 chromatin-associated proteins in one human cell type.

ABSTRACT: Transcription factors are DNA-binding proteins that have key roles in gene regulation^1,2. Genome-wide occupancy maps of transcriptional regulators are important for understanding gene regulation and its effects on diverse biological processes^3-6. However, only a minority of the more than 1,600 transcription factors encoded in the human genome has been assayed. Here we present, as part of the ENCODE (Encyclopedia of DNA Elements) project, data and analyses from chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) experiments using the human HepG2 cell line for 208 chromatin-associated proteins (CAPs). These comprise 171 transcription factors and 37 transcriptional cofactors and chromatin regulator proteins, and represent nearly one-quarter of

SUBMITTER: Partridge EC 

PROVIDER: S-EPMC7398277 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature