Identification of a protein signature for predicting overall survival of hepatocellular carcinoma: a study based on data mining.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC), is the fifth most common cancer in the world and the second most common cause of cancer-related deaths. Over 500,000 new HCC cases are diagnosed each year. Combining advanced genomic analysis with proteomic characterization not only has great potential in the discovery of useful biomarkers but also drives the development of new diagnostic methods.

Methods

This study obtained proteomic data from Clinical Proteomic Tumor Analysis Consortium (CPTAC) and validated in The Cancer Proteome Atlas (TCPA) and TCGA dataset to identify HCC biomarkers and the dysfunctional of proteogenomics.

Results

The CPTAC database contained data for 159 patients diagnosed with Hepatitis-B related HCC and 422 differentially expressed proteins (112 upre

SUBMITTER: Wu ZH 

PROVIDER: S-EPMC7398333 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature