High-Throughput Manufacture of 3D Fiber Scaffolds for Regenerative Medicine.

ABSTRACT: Engineered scaffolds used to regenerate mammalian tissues should recapitulate the underlying fibrous architecture of native tissue to achieve comparable function. Current fibrous scaffold fabrication processes, such as electrospinning and three-dimensional (3D) printing, possess application-specific advantages, but they are limited either by achievable fiber sizes and pore resolution, processing efficiency, or architectural control in three dimensions. As such, a gap exists in efficiently producing clinically relevant, anatomically sized scaffolds comprising fibers in the 1-100 μm range that are highly organized. This study introduces a new high-throughput, additive fibrous scaffold fabrication process, designated in this study as 3D melt blowing (3DMB). The 3DMB system described in this s

SUBMITTER: Shirwaiker RA 

PROVIDER: S-EPMC7398438 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature