Sex-Dependent Macromolecule and Nanoparticle Delivery in Experimental Brain Injury.

ABSTRACT: The development of effective therapeutics for brain disorders is challenging, in particular, the blood-brain barrier (BBB) severely limits access of the therapeutics into the brain parenchyma. Traumatic brain injury (TBI) may lead to transient BBB permeability that affords a unique opportunity for therapeutic delivery via intravenous administration ranging from macromolecules to nanoparticles (NPs) for developing precision therapeutics. In this regard, we address critical gaps in understanding the range/size of therapeutics, delivery window(s), and moreover, the potential impact of biological factors for optimal delivery parameters. Here we show, for the first time, to the best of our knowledge, that 24-h postfocal TBI female mice exhibit a heightened macromolecular tracer and NP accumulat

SUBMITTER: Bharadwaj VN 

PROVIDER: S-EPMC7398445 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature