Systematic meta-analyses, field synopsis and global assessment of the evidence of genetic association studies in colorectal cancer.

ABSTRACT:

Objective

To provide an understanding of the role of common genetic variations in colorectal cancer (CRC) risk, we report an updated field synopsis and comprehensive assessment of evidence to catalogue all genetic markers for CRC (CRCgene2).

Design

We included 869 publications after parallel literature review and extracted data for 1063 polymorphisms in 303 different genes. Meta-analyses were performed for 308 single nucleotide polymorphisms (SNPs) in 158 different genes with at least three independent studies available for analysis. Scottish, Canadian and Spanish data from genome-wide association studies (GWASs) were incorporated for the meta-analyses of 132 SNPs. To assess and classify the credibility of the associations, we applied the Venice criteria and Bayesian False-D

SUBMITTER: Montazeri Z 

PROVIDER: S-EPMC7398467 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature