Project description:CYSKT affected the expressions of genes associated with insulin signaling pathway, increased the amount of phosphorylated insulin receptor in cells and tissues, and stimulated the translocation of glucose transporter 4 to the cell membrane. Moreover, CYSKT affected the expressions of genes related to diabetic complications, improved the levels of renal function indexes, and increased the survival rate of diabetic mice.

2016-12-05 | GSE53119 | GEO

Deletion of small GTPase H-Ras rescues memory deficits and ameliorates amyloid pathology in transgenic Alzheimer’s mice

Project description:This study aimed to invistigate the impact of H-Ras depletion on cognitive function and pathological features of AD.

2022-11-01 | GSE180103 | GEO

Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice.

Project description: Not available

| S-EPMC2883862 | biostudies-literature

Osteopontin deficiency ameliorates Alport pathology by preventing tubular metabolic deficits.

Project description: Not available

| S-EPMC5926939 | biostudies-literature

Expression date from db/db mice with or without treatment of traditional Chinese medicine Tang-shen Formula

Project description:The Chinese herbal granule Tangshen Formula (TSF) has been proven to decrease proteinuria and improve estimated glomerular filtration rate (eGFR) in diabetic kidney disease (DKD) patients with albuminuria. Nevertheless, little was known on the underlying mechanisms of TSF on treating DN. We used microarrays to detail to explore the target genes of TSF in the treatment of DN.

2017-01-25 | GSE90842 | GEO

Istradefylline reduces memory deficits in aging mice with amyloid pathology.

Project description: Not available

| S-EPMC5747997 | biostudies-literature

Phytochemistry, Pharmacology and Quality Control of Xiasangju: A Traditional Chinese Medicine Formula.

Project description: Not available

| S-EPMC9259862 | biostudies-literature