Cardiovascular risk in persons at risk of developing rheumatoid arthritis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is associated with an increased cardiovascular disease (CVD) risk which may start even before diagnosis. To explore this CVD risk prior to RA, we determined multiple risk factors and two 10-year clinical risk scores in a cohort of individuals at-risk of RA. We also analyzed associations with arthritis development and autoantibody status and compared a subset of at-risk individuals to an age and sex matched seronegative control group.

Methods

In a cohort of 555 consecutive arthralgia patients positive for rheumatoid factor (RF) and / or anti-citrullinated protein antibody (ACPA) we retrospectively identified patients with preclinical arthritis (i.e. those who developed arthritis), and non-arthritis patients (those without arthritis develop

SUBMITTER: van Boheemen L 

PROVIDER: S-EPMC7398549 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature