A Systematic Literature Review and Bucher Indirect Comparison: Tildrakizumab versus Guselkumab.

ABSTRACT:

Background

Psoriasis is a chronic inflammatory skin condition that impacts quality of life and requires long-term treatment and effective symptom management. Interleukin-23 (IL-23) has emerged as a key player in the pathogenesis of psoriasis and tildrakizumab and guselkumab are both immunomodulatory agents that inhibit the p19 subunit of IL-23. In its pivotal Phase III trial, tildrakizumab demonstrated greater efficacy than etanercept in moderate-to-severe psoriasis. However, there are no head-to-head trials comparing tildrakizumab with guselkumab.

Methods

We conducted a systematic literature review and Bucher indirect comparison of tildrakizumab and guselkumab, using placebo as a common comparator. We searched MEDLINE, MEDLINE In-Process, MEDLINE(R) Daily Epub Ahead of Prin

SUBMITTER: Du Jardin KG 

PROVIDER: S-EPMC7398610 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature