High-quality human preimplantation embryos stimulate endometrial stromal cell migration via secretion of microRNA hsa-miR-320a.

ABSTRACT:

Study question

How do high-quality human preimplantation embryos influence the endometrium to promote their own implantation?

Summary answer

High-quality human preimplantation embryos secrete a specific microRNA (miRNA), hsa-miR-320a, which promotes migration of human endometrial stromal cells (hESCs).

What is known already

We have previously shown that high-quality human preimplantation embryos excrete unknown factors that influence migration of hESCs.

Study design, size, duration

Embryo excreted miRNAs, specifically those excreted by high-quality embryos, were identified and their effect on hESCs was determined by measuring the migration capacity and gene expression patterns of primary isolated hESCs.

Participants/materials, setting, methods

Embryo con

SUBMITTER: Berkhout RP 

PROVIDER: S-EPMC7398623 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature