Sulfonate-isosteric replacement examined within heroin-hapten vaccine design.

ABSTRACT: Heroin overdose and addiction remain significant health and economic burdens in the world today costing billions of dollars annually. Moreover, only limited pharmacotherapeutic options are available for treatment of heroin addiction. In our efforts to combat the public health threat posed by heroin addiction, we have developed vaccines against heroin. To expand upon our existing heroin-vaccine arsenal, we synthesized new aryl and alkyl sulfonate ester haptens; namely aryl-mono-sulfonate (H_MsAc) and Aryl/alkyl-di-sulfonate (H_(Ds)2) as carboxyl-isosteres of heroin then compared them to our model heroin-hapten (H_Ac) through vaccination studies. Heroin haptens were conjugated to the carrier protein CRM₁₉₇ and the resulting CRM-immunoconjugates were u

SUBMITTER: Belz TF 

PROVIDER: S-EPMC7398700 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature