Insulinemic Potential of Lifestyle Is Inversely Associated with Leukocyte Mitochondrial DNA Copy Number in US White Adults.

ABSTRACT:

Background

Poor lifestyles have been linked to insulin insensitivity/hyperinsulinemia, which may contribute to downstream changes such as inflammation and oxidative damage and the development of chronic diseases. As a biomarker of intracellular oxidative stress, leukocyte mitochondrial DNA copy number (mtDNA-CN) has been related to lifestyle factors including diet and weight. No epidemiologic study has examined the relation between combined insulinemic potential of lifestyle and mtDNA-CN.

Objectives

Our aim was to examine the association between Empirical Lifestyle Index for Hyperinsulinemia (ELIH) and leukocyte mtDNA-CN in US men and women.

Methods

This cross-sectional analysis included 2835 white adults without cancers, diabetes, or cardiovascular disease at blood c

SUBMITTER: Yang K 

PROVIDER: S-EPMC7398789 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature