Prospective Association Between Manganese in Early Pregnancy and the Risk of Preeclampsia.

ABSTRACT:

Background

Manganese, an essential micronutrient, has been found in lower concentrations among women with preeclampsia in cross-sectional and case-control studies without establishment of a temporal relationship.

Methods

We evaluated the prospective association of manganese (in red blood cells) in first trimester of pregnancy with incidence of preeclampsia (ascertained by reviewing medical records) among 1,312 women in eastern Massachusetts (Project Viva, 1999-2002). We used log-binomial regression to examine the manganese-preeclampsia relationship, adjusting for maternal age, race/ethnicity, parity, prepregnancy body mass index, blood pressure, and hematocrit.

Results

The median (25th, 75th percentile) manganese concentrationin red blood cells was 16.2 ng/g (13.1, 20

SUBMITTER: Liu T 

PROVIDER: S-EPMC7398820 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature