MiR-887-3p Negatively Regulates STARD13 and Promotes Pancreatic Cancer Progression.

ABSTRACT:

Purpose

STARD13 is regulated by various miRNAs. However, there are relatively few reports describing the relationship between miRNAs and STARD13 in pancreatic cancer. Therefore, the aim of this study was to explore the relationship between miRNA and STARD13 in pancreatic cancer.

Patients and methods

By analyzing the data from Gene Expression Omnibus (GEO) database, the relationship between STARD13 expression and pancreatic cancer was explored. Then, through sequence alignment, the sequence complementary to miR-887-3p in the 3'UTR of STARD13 mRNA was found, mutated and cloned. Dual-luciferase reporter assay was used to test the relationship between STARD13 and miR-887-3p. Pancreatic cancer tumor tissue and its adjacent tissues collected, and the expression of STARD13 and miR-

SUBMITTER: Xu X 

PROVIDER: S-EPMC7398873 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature