Preclinical support for the therapeutic potential of zolmitriptan as a treatment for cocaine use disorders.

ABSTRACT: Serotonin 1B receptor (5-HT_1BR) agonists enhance cocaine intake in rats during daily self-administration but attenuate cocaine intake after prolonged abstinence. Here we investigated whether the less selective but clinically available 5-HT_1D/1BR agonist, zolmitriptan, produces similar effects. Male and free-cycling female Sprague-Dawley rats were trained to lever press for cocaine (0.75 mg/kg, i.v.) or sucrose (45 mg pellet) reinforcement until performance rates stabilized. Rats then received zolmitriptan (3.0, 5.6, and 10 mg/kg, s.c.) prior to testing for its effects on response and reinforcement rates. Under cocaine testing conditions, rats had access to the training dose for the first hour followed by a lower cocaine dose (0.075 mg/kg, i.v.) for the second hour. Zo

SUBMITTER: Garcia R 

PROVIDER: S-EPMC7398918 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature