Single nucleotide polymorphisms in tinnitus patients exhibiting severe distress.

ABSTRACT: The association between distress caused by tinnitus and psychological factors such as depression and anxiety has been examined and reported. However, prognostic factors remain poorly understood because there are only a few reports on genetic associations. We theorized there might be an association between the grade of tinnitus distress and the genetic background related to psychological factors which might lead us to identify prognostic markers. We enrolled 138 patients who had suffered from tinnitus for over 3 months. Using Tinnitus Handicap Inventory (THI) scores, we examined the association between tinnitus distress and a genetic background related to depression or anxiety. A significant association between single nucleotide polymorphism rs131702 of the Breakpoint Cluster Region (BCR) g

SUBMITTER: Watabe T 

PROVIDER: S-EPMC7398919 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature