TLR7 Negatively Regulates B10 Cells Predominantly in an IFNγ Signaling Dependent Manner.

ABSTRACT: IL-10 producing B cells (B10 cells) play an important immunoregulatory role in various autoimmune and infection conditions. However, the factors that regulate their development and maintenance are incompletely understood. Recently, we and others have established a requirement for TLR7 in promoting autoimmune antibody forming cell (AFC) and germinal center (GC) responses. Here we report an important additional role of TLR7 in the negative regulation of B10 cell development. TLR7 overexpression or overstimulation promoted the reduction of B10 cells whereas TLR7 deficiency rescued these cells in both non-autoimmune and autoimmune-prone mice. TLR7 expression was further inversely correlated with B cell-dependent IL-10 production and its inhibition of CD4 T cell proliferation and IFNγ productio

SUBMITTER: Chodisetti SB 

PROVIDER: S-EPMC7399053 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature