Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H₂S Biogenesis and the Effects Are Transmitted Transgenerationally.

ABSTRACT: Rationale: Gestational cigarette smoke (CS) impairs lung angiogenesis and alveolarization, promoting transgenerational development of asthma and bronchopulmonary dysplasia (BPD). Hydrogen sulfide (H₂S), a proangiogenic, pro-alveolarization, and anti-asthmatic gasotransmitter is synthesized by cystathionine-γ-lyase (CSE), cystathionine-β-synthase (CBS), and 3-mercaptopyruvate sulfur transferase (3MST). Objective: Determine if gestational CS exposure affected the expression of H₂S synthesizing enzymes in the mouse lung and human placenta. Methods: Mice were exposed throughout gestational period to secondhand CS (SS) at approximating the dose of CS received by a pregnant woman sitting in a smoking bar for 3 h/days during pregnancy. Lungs from

SUBMITTER: Singh SP 

PROVIDER: S-EPMC7399059 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature