Gamma radiation improves AD pathogenesis in APP/PS1 mouse model by potentiating insulin sensitivity.

ABSTRACT: Alzheimer's disease (AD) is the largest unmet medical complication. The devastation caused by the disease can be assumed from the disease symptoms like speech impairment, loss of self-awareness, acute memory loss etc. The individuals suffering from AD completely depend on caregivers and have to bear the high cost of treatment which increases the socio-economic burden on the society. Recent studies have shown that radiation exposure can have therapeutic effects when given in suitable amount for a specific time period. Therefore, we investigated the role of gamma irradiation in AD pathogenesis. The effect of radiation on amelioration of disease progression was studied in AD transgenic mice model (APP/PS1). Our in-vivo studies using APP/PS1 mice demonstrated that a single dose of 4.0 Gy gamma

SUBMITTER: Khandelwal M 

PROVIDER: S-EPMC7399127 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature