Evolution of Listeria monocytogenes During a Persistent Human Prosthetic Hip Joint Infection.

ABSTRACT: Listeria monocytogenes associated prosthetic joint infections (PJI) are a rare but increasing clinical problem of listeriosis. We characterized two isolates of the same L. monocytogenes strain isolated within five years of each other from a recurrent human prosthetic joint infection. The two isolates although clonally identical were phenotypically distinct confirming that the original infection strain had evolved within the human host PJI environment giving rise to a phenotypically distinct variant. The recurrent PJI isolate displayed various phenotypic differences compared to the parental original PJI isolate including diminished growth and carbon source metabolism, as well as altered morphology and increased stress sensitivity. The PJI isolates were both diminished in virul

SUBMITTER: Muchaamba F 

PROVIDER: S-EPMC7399150 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature