Re-education of the Tumor Microenvironment With Targeted Therapies and Immunotherapies.

ABSTRACT: The clinical success of cancer immunotherapies targeting PD-1 and CTLA-4 has ignited a substantial research effort to improve our understanding of tumor immunity. Recent studies have revealed that the immune contexture of a tumor influences therapeutic response and survival benefit for cancer patients. Identifying treatment modalities that limit immunosuppression, relieve T cell exhaustion, and potentiate effector functions in the tumor microenvironment (TME) is of much interest. In particular, combinatorial therapeutic approaches that re-educate the TME by limiting the accumulation of immunosuppressive immune cells, such as Foxp3 regulatory T cells (Tregs) and tumor-associated macrophages (TAMs), while promoting CD8⁺ and CD4⁺ effector T cell activity is critical. Her

SUBMITTER: Ngiow SF 

PROVIDER: S-EPMC7399169 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature