Demethylation of the NRF2 Promoter Protects Against Carcinogenesis Induced by Nano-SiO₂.

ABSTRACT: Nano silicon dioxide (Nano-SiO₂) has been widely used in industries such as the field of biomedical engineering. Despite the existing evidence that Nano-SiO₂ exposure could induce oxidative stress and inflammatory responses in multiple organ systems, the carcinogenicity of Nano-SiO₂ exposure has rarely been investigated. Thus in this study, two types of human bronchial epithelial cell lines (16HBE and BEAS-2B) were selected as in vitro models to investigate the carcinogenicity of Nano-SiO₂. Our results revealed that Nano-SiO₂ induces a malignant cellular transformation in human bronchial epithelial cells according to the soft agar colony formation assay. The carcinogenesis induced by Nano-SiO₂ was also confirmed in nu

SUBMITTER: Lou D 

PROVIDER: S-EPMC7399247 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature