Bronchoscopic light delivery method for peripheral lung cancer photodynamic therapy.

ABSTRACT:

Background

Trans-bronchoscope treatment for early stage small peripheral lung cancer, such as photodynamic therapy (PDT), has been investigated. However, despite the efficacy of PDT, light delivery issues limit its application. A method of administering mineral oil with a high refractive index (RI) was previously proposed to enhance light delivery in branched or bent anatomic structures. Lipiodol has a high RI and an exhaustive history of use as a contrast medium for bronchography. We aimed to determine whether the use of lipiodol, like mineral oil, could enhance the illumination effect and therapeutic range of PDT for peripheral lung tumors.

Methods

We injected lipiodol into a pig lung model, guided by a bronchoscope under fluorescent surveillance, to simulate future treatm

SUBMITTER: Chang H 

PROVIDER: S-EPMC7399407 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature