Coarse-Grained Modeling of Pore Dynamics on the Red Blood Cell Membrane under Large Deformations.

ABSTRACT: Transient pore formation on the membrane of red blood cells (RBCs) under high mechanical tensions is of great importance in many biomedical applications, such as RBC damage (hemolysis) and mechanoporation-based drug delivery. The dynamic process of pore formation, growth, and resealing is hard to visualize in experiments. We developed a mesoscale coarse-grained model to study the characteristics of transient pores on a patch of the lipid bilayer that is strengthened by an elastic meshwork representing the cytoskeleton. Unsteady molecular dynamics was used to study the pore formation and reseal at high strain rates close to the physiological ranges. The critical strain for pore formation, pore characteristics, and cytoskeleton effects were studied. Results show that the presence of the cyto

SUBMITTER: Razizadeh M 

PROVIDER: S-EPMC7399477 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature