Inhibition of Host Arginase Activity Against Staphylococcal Bloodstream Infection by Different Metabolites.

ABSTRACT: Staphylococcus aureus is a notorious bacterial pathogen that often causes soft tissue and bloodstream infections and invariably garners resistance mechanisms against new antibiotics. Modulation of the host immune response by metabolites is a powerful tool against bacterial infections, but has not yet been used against S. aureus infections. In this study, we identified four metabolite biomarkers: L-proline, L-isoleucine, L-leucine, and L-valine (PILV), through a metabolomics study using animal models of S. aureus bloodstream infection. The exogenous administration of each metabolite or of PILV showed anti-infective effects, and a higher protection was achieved with PILV in comparison to individual metabolites. During the staphylococcal infection, the expression of most

SUBMITTER: Pang R 

PROVIDER: S-EPMC7399636 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature