Polycystic Kidney Disease Ryanodine Receptor Domain (PKDRR) Proteins in Oomycetes.

ABSTRACT: In eukaryotes, two sources of Ca²⁺ are accessed to allow rapid changes in the cytosolic levels of this second messenger: the extracellular medium and intracellular Ca²⁺ stores, such as the endoplasmic reticulum. One class of channel that permits Ca²⁺ entry is the transient receptor potential (TRP) superfamily, including the polycystic kidney disease (PKD) proteins, or polycystins. Channels that release Ca²⁺ from intracellular stores include the inositol 1,4,5-trisphosphate/ryanodine receptor (ITPR/RyR) superfamily. Here, we characterise a family of proteins that are only encoded by oomycete genomes, that we have named PKDRR, since they share domains with both PKD and RyR channels. We provide evidence that these proteins belong to the TRP superfam

SUBMITTER: Zheng L 

PROVIDER: S-EPMC7399828 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature