Proteome of Glioblastoma-Derived Exosomes as a Source of Biomarkers.

ABSTRACT: Extracellular vesicles (EV) are involved in important processes of glioblastoma multiforme (GBM), including malignancy and invasion. EV secreted by glioblastoma cells may cross the hematoencephalic barrier and carry molecular cargo derived from the tumor into the peripheral circulation. Therefore, the determination of the molecular composition of exosomes released by glioblastoma cells seems to be a promising approach for the development of non-invasive methods of the detection of the specific exosomal protein markers in the peripheral blood. The present study aimed to determine the common exosomal proteins presented in preparations from different cell lines and search potential glioblastoma biomarkers in exosomes. We have performed proteomics analysis of exosomes obtained from the conditi

SUBMITTER: Naryzhny S 

PROVIDER: S-EPMC7399833 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature